邵世鹏，博士，特聘教授，博士生导师，重庆英才计划青年拔尖人才，重庆医科大学生物化学与分子生物学教研室。
诚邀对超分辨成像、基因表达调控、染色质高级结构、相分离、发育障碍疾病等方向感兴趣的同学加入ShaoLab！实验室常年招收博士后和实验助理，热忱期待各位同学和同仁的加入，共同发展！欢迎本科生加入实验室科研训练！
联系方式：ssp@cqmu.edu.cn
教育经历：
2013-2018 |
博士 |
北京大学 |
生命科学学院 |
2009-2013 |
学士 |
四川大学 |
化学与分子工程学院 |
工作经历：
2022-至今 |
特聘教授 |
重庆医科大学基础医学院 |
2021-2022 |
助理研究员 |
北京安贞医院心肺研究所 |
2018-2020 |
博雅博士后 |
北京大学生命科学学院 |
科研兴趣与研究方向：
1开发超分辨探针与成像工具研究染色质高级结构与动态过程
开发和应用活细胞内序列特异性染色质标记和成像技术，研究哺乳动物细胞中染色质位置和结构的动态变化。
2蛋白质液-液相分离在基因表达调控中的机制研究
综合使用活细胞荧光成像、超分辨成像、单分子追踪和体外重构等研究蛋白质液-液相分离机制，以及相分离在控制哺乳动物染色质结构和转录调控等方面的功能。建立基于体外和细胞内的相分离报告系统和高通量药物筛选平台，筛选特异促进或抑制特定蛋白相分离的药物。
3发育障碍疾病相关基因致病机制研究
通过胚胎干细胞模型和小鼠模型研究发育障碍疾病相关蛋白在调控染色质结构和控制基因表达中的功能。结合病人中发现的致病突变，研究特定基因突变带来的功能缺失或获得，深入理解发育障碍疾病的分子机制，并以此作为相关靶点，为临床医学中的诊断和治疗奠定理论基础。
主持基金
1. 国家自然科学基金委，面上项目，2023-2026
2. 国家自然科学基金委，青年项目，2020-2022
3. 第十二届中国博士后基金特别资助，2019-2020
4. 第六十六届中国博士后基金面上项目资助，2019-2020
代表性文章：
1. Hongchen Zhang#, Shipeng Shao#*, Yong Zeng, Xiaotian Wang, Yizhi Qin, Qiunan Ren, Shengqi Xiang, Yuxin Wang, Junyu Xiao, Yujie Sun*. (2022). Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock. Nature Cell Biology, 2022, 24, 340–352.
2. Shipeng Shao, Weiwei Zhang, Huan Hu, Boxin Xue, Jinshan Qin, Chaoying Sun, Yuao Sun, Wensheng Wei, and Yujie Sun, Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 system. Nucleic acids research, 2016. 44(9): p. e86-e86.
3. Lei Chang#, Mengfan Li#, Shipeng Shao#, Boxin Xue, Yingping Hou, Ruifeng Li, Cheng Li, and Yujie Sun, Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells. Protein & cell, 2020. p. 1-23.
4. Shipeng Shao, Lei Chang, Yuao Sun, Yingping Hou, Xiaoying Fan, and Yujie Sun, Multiplexed sgRNA expression allows versatile single nonrepetitive DNA labeling and endogenous gene regulation. ACS synthetic biology, 2017. 7(1): p. 176-186.
5. Shipeng Shao, Hongchen Zhang, Yong Zeng, Yongliang Li, Chaoying Sun, Yujie Sun, TagBiFC technique allows long-term single-molecule tracking of protein-protein interactions in living cells. Communications biology, 2021. 4(1): p. 1-14.
6. Shipeng Shao, Boxin Xue, and Yujie Sun, Intranucleus single-molecule imaging in living cells. Biophysical journal, 2018. 115 (2), p. 181-189.
7. Shipeng Shao, Lei Chang, Yingping Hou, and Yujie Sun, Illuminating the structure and dynamics of chromatin by fluorescence labeling. Frontiers in Biology, 2017. 12(4): p. 241-257. （封面文章）
8. Hongchen Zhang, Shipeng Shao*, Yujie Sun*. (2022). Characterization of liquid-liquid phase separation using super-resolution and single-molecule imaging. Biophysics Reports, 2022, 7, 1-12.（相分离专刊，封面文章）
9. Yuan Wang, Chunlei Zhang, Wenzhong Yang, Shipeng Shao, Xinmin Xu, Yujie Sun, Pilong Li, Ling Liang, Congying Wu, LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force. Developmental Cell, 56 (9), 1313-1325. e7.
10. Mian Wei, Xiaoying Fan, Miao Ding, Ruifeng Li, Shipeng Shao, Yingping Hou, Shaoshuai Meng, Fuchou Tang, Cheng Li, Yujie Sun, Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering. Science Advances, 6 (16), eaay6515.
11. Yongliang Li, Shipeng Shao, Xiao Xu, Xiaodong Su, Yujie Sun, and Shicheng Wei, MapZ Forms a Stable Ring Structure That Acts as a Nanotrack for FtsZ Treadmilling in Streptococcus Mutans. ACS nano, 2018.
12. Lei Chang, Gang Sheng, Yiwen Zhang, Shipeng Shao, Yanli Wang, Yujie Sun, AgoFISH: cost-effective in situ labelling of genomic loci based on DNA-guided dTtAgo protein. Nanoscale Horizons, 4 (4), 918-923.
13. Xue Boxin, Zhou Caiwei, Qin Yizhi, Li Yongzheng, Sun Yuao, Chang Lei, Shao Shipeng, Li Yongliang, Zhang Mengling, Sun Chaoying, He Renxi, Peter Su Qian, Sun Yujie, PN-ImTLSM facilitates high-throughput low background single-molecule localization microscopy deep in the cell. Biophysics Reports, 7 (4), 313-325.
