个人简介

李思桥，研究员、博士生导师、特聘副教授、博士后合作导师；重庆市巴渝学者青年学者、重庆市学术技术带头人后备人选；Journal of Analysis and Testing(JAT)青年编委。迄今，主持国家自然科学基金2项、重庆市科学技术局面上项目2项、重庆市教委科学技术研究项目2项；在国际重要学术期刊（Sci. Adv.; Angew. Chem. Int. Ed.;Mater. Today; Adv. Sci.等）以第一作者/通讯作者发表SCI论文20余篇，其中11篇IF>10、封面文章2篇、高被引1篇，单篇最高IF=26.9（独立一作、封面文章），相关研究被Nature的News and Views专栏进行全文评述。

教育背景及工作经历

2009–2013，成都中医药大学中药学，学士

2013–2016，中国药科大学药物分析学，硕士

2016–2019，南京大学化学，博士

2019–2020，重庆医科大学基础医学院

2020–2025，重庆医科大学基础医学院，副研究员

2021–2023，重庆医科大学基础医学院，硕士生导师

2023至今，重庆医科大学基础医学院，博士生导师

2024至今，重庆医科大学基础医学院，特聘副教授

2025至今，重庆医科大学基础医学院，研究员

学术兼职

2024至今重庆市司法鉴定协会法医毒化鉴定委员会秘书

2020至今重庆法医验伤所法医毒化鉴定人

2025至今Journal of Analysis and Testing (JAT)青年编委

奖项及荣誉

2022年，川渝科技学术大会优秀论文，二等奖，四川省科学技术协会和重庆市科学技术协会(1/5)

2023年，细胞功能分子的识别标记与原位检测技术研究，自然科学二等奖，江苏省科学技术厅(7/9)

2023年，第九届全国大学生基础医学创新研究暨实验设计论坛优秀成果奖，国家级二等奖，高等学校国家级实验教学示范中心联席会(1/7)

主持科研项目

2023年国家自然科学基金面上项目,基于“时-空”可控DNA分级编码的肿瘤源性外泌体蛋白特异性糖型的原位分析技术研究(82372350)

2020年国家自然科学基金青年科学基金项目（C类）,基于适配体介导局域动态DNA纳米自组装的EpCAM低糖基化糖型原位检测新方法研究( 82002254)

2023年重庆医科大学第三批重大科技人才项目“揭榜挂帅”（B类）,肿瘤细胞表面蛋白特异性糖型的原位示踪分析研究

2021年重庆医科大学未来医学青年创新团队项目,骨质疏松个性化精准治疗团队(W0095)

2022年重庆市教育委员会青年项目,基于多色镧系金属-有机框架的便携式智能分析平台用于新精神活性物质的即时检测研究(KJQN202200464)

2023年重庆市教育委员会青年项目,基于多发射Eu/Tb-MOF构建可视化智能分析平台用于炭疽生物标志物检测研究(KJQN202300457)

2021年重庆市科学技术局面上项目,乳腺癌细胞表面EpCAM特异性糖型的原位示踪分析研究(cstc2021jcyj-msxmX0119)

2025年重庆市科学技术局面上项目,乳腺癌细胞表面RNA特异性糖质的原位分析方法研究 (CSTB2025NSCQ-GPX1170)

代表性论文、专利

1.Siqiao Li, Anwen Mao, Fan Huo, Xiaojian Wang, Yuna Guo, Lu Liu, Chao Yan, Lin Ding*, Huangxian Ju. A localized glyco-editing probe for revelation of protein-specific glycan function.Materials Today, 2021, 49, 85-96.(2021IF=26.9,封面文章)

2.Ningke Fan^#, Xintong Bian^#, Meng Li, Junman Chen, Haiping Wu, Qiling Peng, Huijie Bai, Wenqian Cheng, Liangsheng Kong, Shijia Ding,Siqiao Li*, Wei Cheng*. Hierarchical self-uncloaking CRISPR-Cas13a–customized RNA nanococoons for spatial-controlled genome editing and precise cancer therapy.Science Advances, 2022, 8, eabn7382.(2022IF=13.6, Highlight)

3.Kunyang Feng^#, Hanting Wang^#, Song Zhou, Wei Zhang, Chonghai Gong, Yuxin He, Yuseng Wang, Wenchong Dai, Jianbo Li*, Zhengwei Zhang*,Siqiao Li*. Surface engineering-induced d-band center down-regulation in high-entropy alloy nanowires for enhanced nanozyme catalysis.Advanced Science, 2025, 12,2502354.(2024IF=14.1, Frontispiece)

4.Siqiao Li, Yiran Liu, Lu Liu, Yimei Feng, Lin Ding*, Huangxian Ju*. A hierarchical coding strategy for live cell imaging of protein-specific glycoforms.Angewandte Chemie International Edition, 2018, 57, 12007-12011.(2018IF=12.3)

5. Xintong Bian^#, Ningke Fan^#, Meng Li^#, Daobin Han, Jia Li, Lu Fan, Xinyu Li, Liangsheng Kong, Hua Tang, Shijia Ding, Fangzhou Song*,Siqiao Li*, Wei Cheng*. An ER–horse detonating stress cascade for hepatocellular carcinoma nanotherapy.ACS Nano, 2023, 17, 4896-4912.(2023IF=15.8)

6. Ningke Fan, Ketong Yang, Xintong Bian, Yirong Chen, Lu Zhang, Zhujun Ai, Xinyu Li, Shijia Ding*,Siqiao Li*, Wei Cheng*. GlycoSS: a DNA glycosignal sieve for deciphering spatially-resolved EpCAM-specific glycoforms.ACS Nano, 2024, 18, 29106-29120.(2024IF=16.0)

7. Ketong Yang^#, Ningke Fan^#, Xintong Bian, Lu Liu, Menghan Li, Huan Cai, Yan Zhao, Kaili Duan, Yuan Zou*,Siqiao Li*, Shijia Ding*. Dual-confined engineering boosts Cas12a efficiency for precise single exosome-based breast cancer diagnosis.Chemical Engineering Journal, 2025, 517, 164318.(2024IF=13.2)

8. Ting Wang, Lei Zhang, Jieyuan Zhang, Gaoxian Guo, Xinhui Jiang, Zhengwei Zhang*,Siqiao Li*. Highly sensitive fluorescent quantification of carbendazim by two-dimensional Tb-MOF nanosheets for food safety.Food Chemistry,2023, 416, 135853.(2023IF=8.5)

9. Lei Zhang^#, Yuxin He^#, Yue Wu, Jieyuan Zhang,Siqiao Li*, Zhengwei Zhang*. Highly sensitive ratiometric fluorescence detection of tetracycline residues in food samples based on Eu/Zr-MOF.Food Chemistry,2024, 436, 137717.(2024IF=9.8,高被引)

10. Yuxin He, Hecun Zou, Song Zhou, Dongmei Liu, Xinhui Jiang, Zhengwei Zhang*,Siqiao Li*. Smartphone-assisted fluorescent sensor for the visualization and quantitative detection of doxycycline and L-arginine.Food Chemistry,2024, 459, 140365.(2024IF=9.8)

11. Dongmei Liu^#, Xinhui Jiang^#, Xiaoming Li, Hecun Zou, Lin He, Zhengwei Zhang*,Siqiao Li*, Xintong Bian*. A ratiometric fluorescent paper–based sensor based on Fe/Eu-MOF for visual and sensitive detection of diethylstilbestrol.Biosensors and Bioelectronics, 2026, 291, 118017.(2024IF=10.5)

12.Xue Hu^#, Mingmeng Xie^#, Yuxiang Lang, Jieyuan Zhang, Lin He, Xinhui Jiang, Hecun Zou*, Zhengwei Zhang*,Siqiao Li*. Self-confined catalytic DNA circuit for on-site nonenzymatic amplified microRNA imaging.Biosensors and Bioelectronics, 2026, 295, 118265.(2024IF=10.5)

13. Chonghai Gong^#, Qi Wang^#, Qiu Mao, Ziyi Liu, Yu Zhang, Mingmeng Xie,Siqiao Li*, Zhengwei Zhang*. Hierarchically confined noble metal MOF-on-MOF nanozymes with tunable microenvironments for high-throughput pesticide discrimination.Chemical Engineering Journal, 2026, 531, 173790.(2024IF=13.2)

14. Yao Gong^#, Xiaoying Zhang^#, Wenlong Ren, Jian Peng, Miaoshu Liu, Lanxin Jiang, Caixia Pei, Xingping Hu, Jie Xu, Ting Zhang, Fengxia Gao,Siqiao Li*, Li Du*, Wei Cheng*. Bio-orthogonal truncated NKG2D ligand-based nano-igniter unleashes a self-sustaining antitumor immune circuit via NK cell activation.Journal of Controlled Release, 2026, 391, 114603.(2024IF=11.5)