个人简介

副研究员，硕士生导师。先后承担国家自然科学基金青年项目、重庆市科技局项目、重庆市教委科学技术研究项目共4项。围绕“造血干细胞稳态维持机理及其恶性转化后干预”开展研究，以第一作者/通讯作者（含共同）在Journal of Experimental Medicine（2021, 2025）、Nature Communications（2025）、Oncogene（2025）等期刊发表SCI论文13篇。

教育背景及工作经历

2009-2013武汉科技大学生物工程专业学士

2013-2016重庆大学生物医学工程专业硕士

2016-2017陆军军医大学第一附属医院血液科研究实习员

2017-2020重庆大学生物医学工程专业博士

2020-2022陆军军医大学第一附属医院血液科副研究员

2022-至今重庆医科大学副研究员

代表性论文(#共同第一作者，*共同通讯作者)

1.Zhe Chen^#, Feng Wu^#, Yan Li^#, Lei Li^#, Yufei Lei, Siwei Gao, Tao Chen, Yuxin Xie, Jianwen Xiao, Hanqing Zeng, Jianchuan Deng*, Xueya Zhao*, Yu Hou*. Inhibition of DEK restores hematopoietic stem cell function in Fanconi anemia.Journal of Experimental Medicine. 2025;222(3):e20241248.(IF:10.6)

2.Zhe Chen, Dawei Huo, Lei Li, Zhilong Liu, Zhigang Li, Shuangnian Xu, Yongxiu Huang, Wei Wu, Chengfang Zhou, Yuanyuan Liu, Mei Kuang, Feng Wu, Hui Li, Pengxu Qian, Guanbin Song, Xudong Wu*, Jieping Chen*, Yu Hou*. Nuclear DEK preserves hematopoietic stem cells potential via NcoR1/HDAC3-Akt1/2-mTOR axis.Journal of Experimental Medicine, 2021, 218(5): e20201974. (IF:17.8)

3. Lei Li, Yufei Lei, Yan Li, Yuxin Xie, Pusheng Hui, Xiaoyan Zang, Weiru Wu, Feng Wu, Jiankun Fan, Jianming Wang, Jieping Chen*,Zhe Chen*, and Yu Hou*. EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress.Nature Communications. 2025;16(1):6247.(IF:15.7)

4.Yuxin Xie, Runlong Zhao, Yingjiao Zheng, Yan Li, Feng Wu, Yufei Lei, Lei Li, Hanqing Zeng*,Zhe Chen*, Yu Hou*.Targeting KPNB1 suppressesAML cells by inhibiting HMGB2 nuclear import.Oncogene.2025;44(21):1646-1661.(IF:7.2)

5.Zhe Chen#,Qian Guo#, Shichen Huang, Lei Li, Feng Wu, Zhilong Liu, Zhigang Li, Tao Chen, Guanbin Song, Shuangnian Xu*, Jieping Chen*, Yu Hou*. Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin. Genes & Diseases, 2023;11(1):397-412. (IF:6.9)