个人简介
徐蕾,医学博士,副教授,硕士生导师,2007年加入重庆医科大学,为基础医学院免疫与病原生物学系教学骨干,重庆市一流课程负责人,主持省部级教改项目,重庆市优秀基层教学组织成员,校级优秀教师,优秀研究生导师。主持国家及省部级科研课题多项,以第一作者或通讯作者发表SCI论文10余篇,获得国家发明专利授权3项。
教育背景及工作经历
1999-2004重庆医科大学大学临床医学专业学士
2004-2007 重庆医科大学病原生物学专业硕士
2010-2013 重庆医科大学临床医学内科学博士
2007-2009重庆医科大学基础医学院病原生物学教研室助教
2009-2014重庆医科大学基础医学院病原生物学教研室讲师
2014-至今重庆医科大学基础医学院病原生物学教研室副教授
学术兼职
2024-至今重庆市防痨协会基础专委会副主任委员
奖项及荣誉
2023年,重庆医科大学“优秀研究生导师”
2023年,重庆医科大学“优秀毕业论文指导导师”
2024,重庆医科大学“优秀教师”
主持科研项目
2024,重庆市科学技术委员会基础科学与前沿研究项目,CXCL14调控PI3K/Akt/A20途径在分枝杆菌感染中的免疫保护作用及机制研究(CSTB2024NSCQ-MSX0133)
2017,重庆市科学技术委员会,基础科学与前沿研究项目,M.tb32a基因修饰的ΔPE_PGRS47 BCG疫苗预防结核分枝杆菌感染(cstc2017jcyiAX0409)
2010,国家自然科学基金青年基金,PPE68抗原修饰的ΔRpfB卡介苗预防结核分枝杆菌感染的实验研究(30901280)
代表性论文
1.SijiaGao#,YonglinHe,XichuanDeng,NanLu,JiajiaBao,AnlongLi,XintongHe,ShiyanHe,NanzheFu,Felycia Fernanda Hosyanto,LeiXu*;Chemokine CXCL14 Inhibits the Survival of Mycobacterium smegmatis inside Macrophages by upregulating A20 to Promote ROS Production.ACS Infect Dis. 2025,11(4):844-858.
2.XintongHe#,YonglinHe,XichuanDeng,NanLu,AnlongLi,SijiaGao,ShiyanHe,YuranWang,NanzheFu,ZijieWang,YuxinNie,LeiXu*;Rv2741 Promotes Mycobacterium Survival by Modulating Macrophage Functionvia the IL-1α-MAPK Axis.ACSInfectiousDiseases,ACS Infect Dis,2025,11(3):676-688.
3.Lili Wang#,Jiajia Bao,Sijia Gao,Xintong He,Lin Liu,Dan He,Yulian Xu,Qinya Yang,Sifei He,Lei Xu*,Anlong Li*. Identification of regulatorymRNAs and miRNAs that suppress Staphylococcus aureus proliferation via mouse macrophages ferroptosis. Curr Microbiol. 2025,82(4):133.
4.AnlongLi#;JiajiaBao;Sijia Gao ; Ying He ; Xiaoping Nie ; Felycia Fernanda Hosyanto ;XintongHe;TongxinLi;LeiXu*;MicroRNA hsa-miR-320a-3p and Its Targeted mRNA FKBP5 WereDifferentially Expressed in Patients with HIV/TB Co-Infection,ACSInfectiousDiseases,2023,11(3): 768-768
5.AnlongLi#;YonglinHe;ChunYang; Nan Lu ; Jiajia Bao ; Sijia Gao ; Felycia FernandaHosyanto;XintongHe;Huichao Fu ; Huajian Yan ; Ningyu Ding ;Lei Xu*; MethylprednisolonePromotes Mycobacterium smegmatis Survival in Macrophages through NF-κB/DUSP1 Pathway,Microrganisms,2023,11(3): 768-768
6.JiajiaBao#;YonglinHe;ChunYang; Nan Lu ; Anlong Li ; Sijia Gao ; Felycia FernandaHosyanto ; Jialing Tang ; Junzhuo Si ; Xia Tang ; Huichao Fu ;Lei Xu*; Inhibition of mycobacteria proliferation in macrophages by low cisplatin concentration through phosphorylated p53-related apoptosis pathway,PLoSOne,2023,18(1):e0281170
7.MinDing#;Hong-xuWang;Si-jia Gao ; Xiao-fei Lai ; An-long Li ; Jia-jia Bao ; Felycia-Fernanda Hosyan ;Lei Xu*; Significant elevated CXCL14 and decreased IL-39 levels in patients with tuberculosis,Openlifescience,2023,18(1): 20220594-20220594.
8.Lei Xu#,Zeng Tu,Ge Xu,Jie-Li Hu,Xue-Fei Cai,Xing-Xing Zhan,Yu-Wei Wang,Yuan Huang,Juan Chen,Ai-Long Huang*.S-phase arrest after vincristine treatment may promote hepatitis B virus replication. World J Gastroenterol. 2015;21(5):1498-509.
9.Hu Y#,Xu L#, He YL, Pang Y, Lu N, Liu J, Shen J, Zhu DM, Feng X, Wang YW, Yang C*.Prevalence and Molecular Characterization of Second-Line Drugs Resistance among Multidrug-Resistant Mycobacterium tuberculosis Isolates in Southwest of China.Biomed Res Int. 2017:4563826.
10.Xiaofei Lai#, Felycia Fernanda Hosyanto,Lei Xu*.Risk of Clostridium tetani infection in an elderly patient following hemorrhoid ligation.JInt Med Res. 2020;48(10):300060520963983.
11.Yuwei Wang#,Chun Yang,Yonglin He,Xingxing Zhan,Lei Xu*. Ipr1 modified BCG as a novel vaccine induces stronger immunity than BCG against tuberculosis infection in mice.Mol Med Rep,2016;14(2):1756-64.
12.Li X#, Pan E#, Zhu J#,Xu L#, Chen X, Li J, Liang L, Hu Y, Xia J, Chen J, Chen W, Hu J, Wang K, Tang N, Huang A.Cisplatin Enhances Hepatitis B Virus Replication and PGC-1α Expression through Endoplasmic Reticulum Stress. Sci Rep. 2018 Feb 22;8(1):3496.
专利
1.徐蕾;李安龙;包嘉佳;赖晓霏; 4-异硫脲基丁腈盐酸盐在治疗分枝杆菌感染中的应用,2023-3-21,中国,ZL 202111534092.8,已授权
2.徐蕾;高思佳;赖晓霏; CXCL14作为生物标志物在结核病诊断中的用途,2021-12-17,中国,ZL 202111554819 .9,已授权
3.徐蕾;何忻桐;陈丹;李安龙;高思佳; (E)-2-亚苄基-3- (环己基氨基)-2,3-二氢- 1H-茚-1-酮在治疗分枝杆菌感染中的应用,2023-2-19,中国,ZL 202310135247 .3,已授权