个人简介
副教授，硕士研究生导师，生物学博士。博士毕业于中国科学院大学，之后在美国康奈尔大学与密西根大学从事博士后研究。2021年8月加入浙江大学医学院附属第一医院任特聘副研究员，2025年7月加入重庆医科大学基础医学院免疫学教研室任特聘副教授。研究工作运用多学科交叉手段，围绕内质网稳态与免疫调节，深入研究内质网蛋白质质量控制相关信号通路在多类免疫细胞及免疫通路中的调节作用，为抗肿瘤免疫以及核酸感知受体相关炎症疾病的干预提供了新的靶点。以第一作者或通讯作者（含共同）在Nature Communications (2025), Cell Death & Disease (2025),Trends in Cell Biology (2024)，Nature Cell Biology(2023), Science Advances(2021)等国际著名期刊发表多篇研究论文。
教育背景及工作经历
2003-09~2007-06 长江大学农学学士
2007-09~2012-06 中国科学院大学生物学博士
2013-10~2016-10 康奈尔大学博士后
2016-12~2021-07 密歇根大学博士后
2021-8~2025-06 浙大附一院特聘副研究员
2025-07~至今重庆医科大学特聘副教授
学术兼职
2023-至今，细胞生物学会会员
2023-至今，全国免疫学会会员
2025-至今，重庆市免疫学会会员
主持科研项目
国家自然科学基金青年项目“内质网感受器IRE1a对胰腺癌化疗抵抗的调控与机制研究（2024-2026）
重庆医科大学引进人才启动基金（2025-2029）
浙大附一院引进人才启动基金（2021-2025）
代表性论文、专利
1. Lianfeng Zhao, Zinan He, Yao Sun, Mengqi Sun, Zhangsen Zhou, Ling Qi,Yuan Luo#,Yewei Ji#, Tingbo Liang#. The HRD1 quality control pathway is essential for TLR3-mediated innate immunity by regulating its trafficking.Nature Communications.(已接收,#, co- corresponding author)
2.Yuan Luo#,Mengqi Sun, Lei Chang, Zinan He, Xinghang Zhou, Yaming Yuan, Huijuan Sun, Shiqi Luo, Jinyan Huang, Hongkun Wu, Wenjun Liu, Zhangsen Zhou, Yuanhui Mao, Yewei Ji#, Tingbo Liang#.IRE1α translational suppression potentiates STING-dependentchemoresistance in pancreatic cancer.2025.Cell Death and Disease,16:680(#, co-corresponding author)
3.Yuan Luo*,Lei Chang*, Yewei Ji#, Tingbo Liang#.ER: a critical hub for STING signaling regulation.2024.Trends incell Biology,34(10): 868-881(*, co-first author)
4.Yewei Ji*,Yuan Luo*,Yating Wu, Yao Sun, Lianfeng Zhao, Zhen Xue, Mengqi Sun, Xiaoqiong Wei, Zinan He, Shuangcheng Alivia Wu, Liangguang Leo Lin, You Lu, Lei Chang, Fei Chen, Siyu Chen, Wei Qian, Xiaoxi Xu, Shengnuo Chen, Dongli Pan, Zhangsen Zhou, Sheng Xia, Chih-Chi Andrew Hu, Tingbo Liang, Lin Qi#. SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of activable STING pool. 2023.Nature Cell Biology.2023 May (25) 726-739. doi:10.1038/s41556-023-01138-4 (*, co-first author)
5.Yuan Luo,Jacob C. Johnson, Tuhin S. Chakraborty, Austin Piontkowski, Christi M. Gendron and Scott D. Pletcher. Yeast volatiles double starvation survival inDrosophila. 2021.Science Advances, 7(eabf8896): 1-13
6.Yuan Luo,Qingguo Chen, Junbo Luan, Seung Ho Chung, Joyce Van Eck, R. Turgeon, Angela E. Douglas. Towards an understanding of the molecular basis of effective RNAi against a global insect pest, the whiteflyBemisia tabaci. 2017.Insect Biochemistry and Molecular Biology,88(2017): 21-29
7.Adam C.-N. Wong*,Yuan Luo*,Xiangfeng Jing, Soeren Franzenburg, Alyssa Bost, Angela E. Douglas. The host as the driver of the microbiota in the gut and external environment ofDrosophila melanogaster.2015.Applied and Environmental Microbiology,81(18): 6232-6240(*, co-first author)
8.Yuan Luo,Xianhui Wang, Xuesong Wang, Dan Yu, Bing Chen, Le Kang. Differential responses of migratory locusts to systemic RNA interference via double-stranded RNA injection and feeding. 2013.Insect molecular biology, 22(5): 574- 583
9.Yuan Luo,Xianhui Wang, Dan Yu, Le Kang. The SID-1 double-stranded RNA transporter is not required for systemic RNAi in the migratory locust. 2012.RNA Biology, 9(5): 663-671
