个人简介
特聘副教授、硕士生导师、理学博士，2025年加入重庆医科大学基础医学院。研究兴趣主要为肿瘤免疫和肿瘤动态演化的表观遗传调控。主持国家自然科学基金青年科学基金项目（C类）1项，中国博士后科学基金面上项目1项。在Genome Biology, Cell Death & Differentiation, Molecular Cancer Research等学术刊物发表学术论文16篇。
教育背景及工作经历
2010-2014西北农林科技大学生物技术学士
2014-2016西北农林科技大学/中国农业科学院 蔬菜学（植物基因组学）硕士
2016-2020德国哥廷根大学基因组科学（IMPRS - Genome Science） 博士
2020-2021德国哥廷根大学医学院博士后
2021-2022广东省人民医院/广东省医学科学院 医学研究部 特聘副研究员
2022-2024中国科学院深圳先进技术研究院合成生物学研究所博士后
2024-2025中国科学院深圳先进技术研究院合成生物学研究所助理研究员
2025-至今重庆医科大学基础医学院特聘副教授
主持科研项目
2024年，国家自然科学基金青年科学基金项目（C类），结直肠癌化疗耐药过程的克隆演化动态及表观遗传调控机制研究
2022年，中国博士后科学基金面上资助，基于单细胞谱系追踪的胰腺癌化疗耐药性演化机制的研究
代表性论文
1.Li, S., Wang, K.,Wang, X.*,Hu, Z.*(2025).Single-cell mitochondrial lineage tracing: Opportunities and challenges.Quantitative Biology.
2.Wang,X,#,Wang,K.#,Zhang,W.#,Tang,Z.,Zhang,H.,Cheng,Y.,Zhou,D.,Zhang,C.,Zhong,W.-Z.,Ma,Q.*,Xu,J.*,Hu, Z.*(2025).Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells.Genome Biology.
3.Ekstrom, T. L., Rosok, R. M., Abdelrahman, A. M., Parassiadis, C., Manjunath, M., Dittrich, M. Y.,Wang, X., Kutschat, A. P., Kanakan, A., Rajput, A., Schacherer, N., Lukic, T., Carlson, D. M., Thiel, J., Kopp, W., Stroebel, P., Ellenrieder, V., Gaedcke, J., Dong, M., Najafova, Z., … Johnsen, S. A.*(2025). Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer.Gut.
4.Wang, X.#, Kutschat, A. P.#, Aggrey-Fynn, J., Hamdan, F. H., Graham, R. P., Wixom, A. Q., Souto, Y., Ladigan-Badura, S., Yonkus, J. A., Abdelrahman, A. M., Alva-Ruiz, R., Gaedcke, J., Ströbel, P., Kosinsky, R. L., Wegwitz, F., Hermann, P., Truty, M. J., Siveke, J. T., Hahn, S. A., Hessmann, E., … Najafova, Z.*(2023). Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma.Molecular Cancer Research.
5.Guo, W.#,Wang, X.#, Lu, B., Yu, J., Xu, M., Huang, R., Cheng, M., Yang, M., Zhao, W.*, & Zou, C.*(2023). Super-enhancer-driven MLX mediates redox balance maintenance via SLC7A11 in osteosarcoma.CellDeath & Disease.
6.Wang, K., Hou, L.,Wang, X., Zhai, X., Lu, Z., Zi, Z., Zhai, W., He, X., Curtis, C., Zhou, D.*, & Hu, Z.*(2023). PhyloVelo enhances transcriptomic velocity field mapping using monotonically expressed genes.Nature Biotechnology.
7.Zhang, Z.,Wang, X., Hamdan, F. H., Likhobabina, A., Patil, S., Aperdannier, L., Sen, M., Traub, J., Neesse, A., Fischer, A., Papantonis, A., Singh, S. K., Ellenrieder, V., Johnsen, S. A., & Hessmann, E.*(2023).NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming.Cellular and Molecular Gastroenterology and Hepatology.
8.Hamdan, F. H., Abdelrahman, A. M., Kutschat, A. P.,Wang, X., Ekstrom, T. L., Jalan-Sakrikar, N., Wegner Wippel, C., Taheri, N., Tamon, L., Kopp, W., Aggrey-Fynn, J., Bhagwate, A. V., Alva-Ruiz, R., Lynch, I., Yonkus, J., Kosinsky, R. L., Gaedcke, J., Hahn, S. A., Siveke, J. T., Graham, R., … Johnsen, S. A.*(2023). Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer.Gut.
9.Wang, X.#,Kutschat, A., Yamada, M., Prokakis, E., Boettcher, P., Tanaka, K., Doki, Y., Hamdan, F., and Johnsen, S.A.*(2021). Bromodomain protein BRDT directs ΔNp63 function and super enhancer activity in a subset of esophageal squamous cell carcinomas.Cell Death & Differentiation.
10.Kutschat, A.#, Hamdan, F.#,Wang, X.,Wixom, A., Najafova, Z.,Gibhardt, C., Kopp, W., Gaedcke, J., Stroebel, P., Ellenrieder, V., Bogeski, I., Hessmann, E. and Johnsen, S.A.*(2021).Calcium-dependent epigenetic reprogramming in pancreatic cancer.Cancer Research.
11.Patil, S., Steuber, B., Kopp, W., Kari, V., Urbach, L.,Wang, X., Küffer, S., Bohnenberger, H., Spyropoulou, D., Zhang, Z., Versemann, L., Bösherz, M., Brunner, M., Gaedcke, J., Ströbel, P., Zhang, J., Neesse, A., Ellenrieder, V., Singh, S., Johnsen, S.A.and Hessmann, E.*(2020).EZH2 regulates pancreatic cancer subtype identity and tumor progression via transcriptional repression of GATA6.Cancer Research.
12.Kosinsky, R.L., Zerche, M., Saul, D.,Wang, X., Wohn, L., Wegwitz, F., Begus-Nahrmann, Y. and Johnsen, S.A.*(2020).USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.Cell Death & Differentiation.
13.Sen, M.,Wang, X., Hamdan, F.H., Rapp, J., Eggert, J., Kosinsky, R.L., Wegwitz, F., Kutschat, A.P., Younesi, F.S., Gaedcke, J., Grade, M., Hessmann, E., Papantonis, A.,Ströbel, P. and Johnsen, S.A.*(2019). ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells.Clinical Epigenetics.
14.Wang, X.#, Gao, D.#, Sun, J., Liu, M., Lun, Y., Zheng, J., Wang, S., Cui, Q., Wang, X.*and Huang, S.*(2016). An exon skipping in a SEPALLATA‐Like gene is associated with perturbed floral and fruits development in cucumber.Journal of Integrative Plant Biology.
15.Lun, Y.#,Wang, X.#, Zhang, C., Yang, L., Gao, D., Chen, H. and Huang, S.*(2016).A CsYcf54 variant conferring light green coloration in cucumber.Euphytica.
16.Wang, Q., Wang, S., Gan, S.,Wang, X., Liu, J. and Wang, X.*(2016). Role of specific phosphorylation sites of Arabidopsis brassinosteroid-insensitive 1 receptor kinase in plant growth and development.Journal of Plant Growth Regulation.
