个人简介
罗静,女,博士,临床医学博士后,助理研究员。现任职于重庆医科大学基础医学院病理学系,长期从事缺血性脑卒中与神经免疫调控相关研究,重点关注线粒体稳态、炎症小体激活及神经保护机制。曾国家公派留学赴牛津大学医学院Radcliffe Department of Medicine临床神经科学系联合培养。主持中国博士后科学基金面上项目地区专项计划1项、重庆市自然科学基金面上项目1项,参与重庆市科技创新重大专项“脑功能障碍数字诊疗装备”。以第一作者或共同第一作者在Journal of Affective Disorders、Journal of Ethnopharmacology、BBA - Molecular Basis of Disease、Neuroscience等期刊发表多篇论文。
教育背景及工作经历2018.09-2023.07 重庆医科大学,病理学与病理生理学,博士
2012.09-2017.06 川北医学院,临床医学,学士
2025.08-至今重庆医科大学基础医学院,助理研究员
2023.08-2025.06 重庆医科大学附属第一医院,博士后
2022.12-2023.12 牛津大学医学院Radcliffe Department of Medicine,联合培养博士/助教
2018.09-2023.07 重庆医科大学,基础医学院/附属第一医院相关团队,开展线粒体稳态与神经免疫调控机制研究
奖项及荣誉
重庆医科大学研究生拔尖人才培养计划(BJRC202112)
英国第六届Preclinical Stroke Symposium海报展示奖(£150 ECR bursary)
主持项目
1.中国博士后科学基金面上项目,第75批面上资助“地区专项支持计划”,编号:2024MD754024,2024.07-2025.06,8万元。
2.重庆市自然科学基金面上项目,小胶质细胞中RNF13在缺血性脑卒中后促进炎性损伤的调控机制研究,编号:CSTB2024NSCQ-MSX1250,2024.07-2027.06,10万元。
参与项目
1.重庆市技术创新与应用发展专项重大项目,脑功能障碍数字诊疗装备,编号:CSTB2024TIAD-STX0044,2024.11-2027.11,8000万元,参与。
代表性论文
1.Luo J, Zheng Y, Chen J, Xiong X, et al. Mitochondrial biological functions in diverse stroke subtypes: from associations to potential mechanisms. Journal of Affective Disorders. 2026;396:120832.(唯一第一作者)
2.Luo J#, Zheng Y, Chen J, Xiong X, Shen J, Hong D, Jiang N, Li W, Zhao J, Wu J. Neuroprotective Role of Da Qin Jiu Decoction in Ischemic Stroke: Mitochondrial Rescue through PI3K/Akt-Mediated UPRmt Activation. Journal of Ethnopharmacology. 2025;343:119433.(共同第一作者,排位第一)
3.Luo J#, Luo Y, Chen J, Gao Y, Tan J, et al. Intestinal metabolite UroB alleviates cerebral ischemia/reperfusion injury by promoting competition between TRIM65 and TXNIP for binding to NLRP3 inflammasome in response to neuroinflammation. BBA - Molecular Basis of Disease. 2024;1870(4):167056.(共同第一作者,排位第一)
4.Chen J, Wu C, He J, Wu L, Yang Y, Zhong S,Luo J*. Causal associations of thyroid function and sudden sensorineural hearing loss: a bidirectional and multivariable Mendelian randomization study. Front Neurol. 2023 Nov 27;14:1269545.(共同通讯作者,排位第一)
5.Luo J, Jiang N, Chen J, Gao Y, Zhao J, Yang C, Zhao Y. Inhibition of miR-423-5p exerts neuroprotective effects in an experimental rat model of cerebral ischemia/reperfusion injury. Neuroscience. 2022;503:95-106.(唯一第一作者)
6.Luo J, Tan J, Jiang N, Yang C, Chen J, Zhao J, Li L, Zhao Y. Platonin protects against cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasomes via BNIP3/LC3 signaling mediated autophagy. Brain Research Bulletin. 2022;180:12-23.(唯一第一作者)
7.Luo J, Chen J, Yang C, Tan J, Zhao J, Jiang N, Zhao Y. 6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy. Int Immunopharmacol. 2021 Nov;100:108146.(唯一第一作者)
8.Zhang L, Chen J, Zhong S,Luo J*, Tang P. Causal associations of white blood cell count and sudden sensorineural hearing loss: a bidirectional and multivariable Mendelian randomization study. Front Neurol. 2024 Sep 27;15:1387244.(共同通讯作者,排位第二)
9.Chen J, Wu C, He J, Wu L, Yang Y, Zhong S,Luo J*. Causal associations of thyroid function and sudden sensorineural hearing loss: a bidirectional and multivariable Mendelian randomization study. Front Neurol. 2023 Nov 27;14:1269545.(共同通讯作者,排位第一)
10.Huang X, Tan J, Ji Y,Luo J, Zhao Y, Zhao J. BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome. CNS Neurosci Ther. 2024 Mar;30(3):e14697.
11.Chen J,Luo J, He J, Jiang X, Jiang N, Yang C, Zhong S. Cell Cycle-Related Gene SPC24: A Novel Potential Diagnostic and Prognostic Biomarker for Laryngeal Squamous Cell Cancer. Biomed Res Int. 2023 Jan 21;2023:1733100.
12.Gao Y, Xiao X,Luo J, Wang J, Peng Q, Zhao J, Jiang N, Zhao Y. E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury. Int J Mol Sci. 2022 Nov 7;23(21):13648.
13.Tan J,Luo J, Meng C, Jiang N, Cao J, Zhao J. Syringin exerts neuroprotective effects in a rat model of cerebral ischemia through the FOXO3a/NF-κB pathway. Int Immunopharmacol. 2021 Jan;90:107268.
14.Chen J, He J,Luo J, Zhong S. Association of αENaC p. Ala663Thr Gene Polymorphism With Sudden Sensorineural Hearing Loss. Front Genet. 2021 Dec 22;12:659517.
15.Yang C, Chen J, Yu Z,Luo J, Li X, Zhou B, Jiang N. Mining of RNA Methylation-Related Genes and Elucidation of Their Molecular Biology in Gallbladder Carcinoma. Front Oncol. 2021 Feb 25;11:621806.
专利/软著
1.罗静.基于纳米孔测序技术的端粒序列分析软件[简称:NanoTelo_base] V1.0.软件著作权,登记号:2025SR2339413。