个人简介
副研究员、医学博士。中国微生物协会终身会员，主要从事益生菌开发，新型病毒疫苗和药物研发。主持青年基金，博士后面上基金等，发表多篇SCI论文，参与病原生物学教学科研工作。
教育背景及工作经历
2009-09至2013-06,西北农林科技大学,水产养殖,学士
2013-09至2016-06,西北农林科技大学,水生生物,硕士
2016-09至2020-06,中国科学院大学,遗传学,博士
2020-07至2020-10,中国科学院大学,昆明动物研究所,助理研究员
2020-11至2023-12,第四军医大学，博士后
2023-12至2024-09,重庆医科大学,基础医学院
2024-10至今,重庆医科大学,基础医学院,副研究员
主持科研项目
中国博士后科学基金会,面上资助, 2022M713848, GBP1通过结合NP抑制HTNV感染的机制研究, 2022-07至2024-07, 8万元,结题,主持
国家自然科学基金委员会,青年科学基金项目（C类）[原青年科学基金项目], 82302525, GSK3β通过磷酸化降解NP抑制汉滩病毒感染的作用和机制研究, 2024-01-01至2026-12-31, 30万元,在研,主持
代表性论文、专利
1. Yihong Cui; Qianying Jia; Han Yan; Xinping Hua; Yu Tan; Wenwen Jian; Xue Gong; Kim Hayer; Siyi Xing; Yi Zhang; Jing Liu; Yuan Wu; Abbas Yadegar;Tianle Gu*; Zeng Tu*; NovelEnterococcus faeciumP2 as a probiotic for mitigating Clostridioides difficile infection, Microbial Pathogenesis, 2025, 208(108028).
2.Tianle Gu#*; Sirui Qu#; Junmei Zhang; Qikang Ying; Xiaoxiao Zhang; Yunhua Lv; Rongrong Liu; Yunan Feng; Fang Wang*; Xingan Wu*; Guanylate-binding protein 1 inhibits Hantaan virus infection by restricting virus entry, journal of medical virology, 2024, 96(e29730).
3. Liu, Qianjin#;Gu, Tianle#; Su, Ling-Yan; Jiao, Lijin; Qiao, Xinhua; Xu, Min; Xie, Ting; Yang, Lu-Xiu; Yu, Dandan; Xu, Ling; Chen, Chang; Yao, Yong-Gang; GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation, Redox Biology, 2021,47(102172).
4.Gu, Tianle; Yu, Dandan; Xu, Ling; Yao, Yu-Lin; Yao, Yong-Gang; Tupaia GBP1 interacts with STING to initiate autophagy and restrict herpes simplex virus type 1 infection., The Journal of Immunology, 2021, 207(11).
5.Gu, Tianle; Yu, Dandan; Xu, Ling; Yao, Yu-Lin; Zheng, Xiao; Yao, Yong-Gang; Tupaia guanylate-binding protein 1 interacts with vesicular stomatitis virus phosphoprotein and represses primary transcription of the viral genome., Cytokine, 2021, 138(155388).
6.Gu, Tianle, Yu, Dandan, Fan, Yu, Wu, Yong, Yao, Yu-Lin, Xu, Ling, Yao, Yong-Gang. Molecular identification and antiviral function of the guanylate-binding protein (GBP) genes in the Chinese tree shrew (Tupaia belangeri chinesis). Dev Comp Immunol. 2019; 96:27-36.
7.Gu, Tianle, Yu, Dandan, Li, Yu, Xu, Ling, Yao, Yu-Lin, Yao, Yong-Gang. Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis). Appl Microbiol Biotechnol. 2019;103(5):2171-2180.
