袁海心，特聘教授，博士生导师。2002年毕业于中国科学技术大学，获理学学士学位；2009年毕业于中国科学院上海生化细胞研究所，获生物化学与分子生物学博士学位；2009-2014年在美国加州大学圣迭戈分校做博士后，从事细胞生长与细胞自噬的调控机制研究。2014年11月受聘于复旦大学生物医学研究院，任青年研究员/PI；2019年12月晋升为研究员/PI。2022年1月加入重庆医科大学，先后任生命科学研究院和药学院特聘教授。

袁海心教授关注肿瘤细胞代谢与死亡的调控机制以及化学干预研究，已发表学术论文逾40篇，其中通讯及一作论文25篇。获得国家自然科学基金面上项目（4项）、国家科技重大专项和国家重点研发计划等资金支持，并入选上海高校特聘教授（东方学者）、上海市人才发展资金、重庆市学术技术带头人后备人选、重庆市留创计划（重点项目）以及重庆医科大学重大科技人才项目“揭榜挂帅”（A类）等人才计划。

代表性论文（*通讯作者）：

1. Cen SY, Lin F, Li X, Hu Y, Liu JP, Xue Z, Gao Y, Sun YP, Zhu S, Dang Y, Zhao Y, Yuan HX*. Crizotinib and its enantiomer suppress ferroptosis by decreasing PE-O-PUFA content. Cell Death Discov. 2024, 10(1):360.

2. Duan KL^#, Wang TX^#, You JW^#, Wang HN, Wang ZQ, Huang ZX, Zhang JY, Sun YP, Xiong Y, Guan KL, Ye D, Cheng L*, Liu R*, Yuan HX*. PCK2 maintains intestinal homeostasis and prevents colitis by protecting antibody-secreting cells from oxidative stress. Immunology 2024, 173(2):339-359. (*co-corresponding)

3. Liu JP^#, Cen SY^#, Xue Z, Wang TX, Gao Y, Zheng J, Zhang C, Hu J, Nie S, Xiong Y, Guan KL, Yuan HX*. A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4. ACS Chem Biol. 2022, 17(12):3389-3406.

4. Sun SJ^#, Ai Y^#, Duan KL, Zhang JY, Zhang C, Sun YP, Xiong Y, Guan KL, and Yuan HX*. TET2 deficiency sensitizes tumor cells to statins by reducing HMGCS1 expression. Oncogene 2022, 41:5385-5396.

5. Wang TX^#, Duan KL^#, Huang ZX, Xue ZA, Liang JY, Dang Y, Zhang A, Xiong Y, Ding C*, Guan KL and Yuan HX*. Tanshinone functions as a coenzyme that confers gain-of-function of NQO1 to suppress ferroptosis. Life Sci Alliance 2022, 6:e202201667.

6. Hu M^#, Bao R^#, Lin M^#, Han XR, Ai YJ, Gao Y, Guan KL, Xiong Y, and Yuan HX*. ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3. Oncogene 2022, 41:4547-4559.

7. Liu P^#, Sun SJ^#, Ai Y^#, Feng X, Zheng YM, Gao Y, Zhang JY, Zhang L, Sun YP, Xiong Y, Lin M*, and Yuan HX*. Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance. Cell Death Dis. 2022, 13:205. (*co-corresponding)

8. Li X, Wang TX, Huang X, Li Y, Sun T, Zang S, Guan KL, Xiong Y, Liu J*, and Yuan HX*. Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. Liver Int. 2020, 40:1378-1394. (*co-corresponding)

9. Wang TX, Liang JY, Zhang C, Xiong Y, Guan KL, and Yuan HX. The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. Cell Death Dis. 2019, 10:755.

10. Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, and Yuan HX. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018, 9:508.