个人简介
副教授、硕士生导师、理学博士。2013年加入重庆医科大学，现任基础医学院组织学与胚胎学教研室副主任。任中国解剖学会医学发育生物学分会委员。主持国家自然科学基金青年项目1项、面上项目1项，省部级科研项目3项，市局级科研项目1项。在SCI刊物ARS, JHM, EP, ETP等发表研究论文近50篇。指导或联合指导硕士、博士研究生十余名。主要研究方向为早期卵子发生的调控机理、环境污染物对早期卵子发生的影响及分子机制。
教育背景及工作经历
2003-2007 中国农业大学，生物技术，学士
2007-2012 中国农业大学，生理学，博士
2013-2018 重庆医科大学，基础医学院，组织学与胚胎学教研室讲师
2023-2024 澳大利亚蒙纳士大学生物医学与发现研究所访问学者
2018-至今 重庆医科大学，基础医学院，组织学与胚胎学教研室副教授
学术兼职
2022-至今 中国解剖学会医学发育生物学分会委员
2021-至今 SCI期刊《Frontiers in cell and developmental biology》任review editor。
奖项及荣誉
2022年，重庆医科大学优秀共产党员
2023年，重庆市高等院校虚拟仿真一流课程负责人
主持科研项目
2025年，国家自然科学基金面上项目，YTHDF2/NANOS3介导的P小体组装调控马兜铃酸I暴露的仔鼠卵巢RNA代谢（82471688）
2024年，重庆市自然科学基金面上项目，烟酰胺通过活化Sirtuin7逆转对乙酰氨基酚干扰胎鼠卵子发生的机制研究（cstb2024nscq-msX0149）
2020年，重庆市自然科学基金面上项目，妊娠期马兜铃酸I暴露抑制胚胎卵母细胞第一次减数分裂前期的机制（cstc2020jcyj-msxmX0135）
2016年，国家自然科学基金青年项目, 雌二醇抑制胚胎小鼠卵母细胞第一次减数分裂前期的机制（31601200）
2015年，重庆市基础与前沿一般项目，雌激素及其类似物抑制胚胎小鼠卵母细胞第一次减数分裂前期的机制（cstc2016jcyjA0318）
2015年，重庆市教委科学技术研究项目，环境激素DEHP对小鼠原始卵泡形成的影响及其机制（KJ1500226）
代表性论文
1. Dai Yuhan#, He Junlin, He Fei, Chen Zhuxiu, Jiang Yu, Geng Yanqing, Geng Jianwei, Zhou Yongrui, Chen Xuemei, Li Fangfang, Wang Yingxiong, Mu Xinyi*. Exposure to environmentally relevant levels of GenX affects placental and offspring development in mice. Environ Pollut. 2024 Dec 15;363(Pt 2):125294. doi: 10.1016/j.envpol.2024.125294.
2. Dai Yuhan#, He Junlin, Chen Xuemei, Geng Yanqing, Chen Zhuxiu, Liu Fangfei, Li Fangfang, Wang Yingxiong, Mu Xinyi*. Maternal administration of APAP induces angiogenesis disorders in mouse placenta via SOCS3/JAK1/STAT3 pathway. Reprod Toxicol. 2024 Oct;129:108668. doi: 10.1016/j.reprotox.2024.108668.
3. He Fei#, Mu Xinyi#, Zhang Yan, Wang Yingxiong, Geng Jianwei, Geng Yanqing, Ma Yidan, Yin Xin, Gao Rufei, Chen Xuemei, He Junlin*. Late gestational exposure to fenvalerate impacts ovarian reserve in neonatal mice via YTHDF2-mediated P-body assembly. Sci Total Environ. 2024 May 15;925:171790. doi: 10.1016/j.scitotenv.2024.171790.
4. Liu Fangfei#, He Junlin, Chen Xue, Liu Ronglu, Li Fangfang, Geng Yanqing, Dai Yuhan, Zhang Yan, Wang Yingxiong, Mu Xinyi*. Maternal Administration of Acetaminophen Affects Meiosis Through its Metabolite NAPQI Targeting Sirtuin7 in Fetal Oocytes. Antioxid Redox Signal. 2024 Feb 13. doi: 10.1089/ars.2023.0270.
5. Liu Ronglu#, Mu Xinyi#, Gao Rufei, Geng Yanqing, Zhang Yan, Chen Xuemei, Yin Xin, Wang Hong, Li Fangfang, He Junlin*. Maternal exposure to cetylpyridinium chloride impairs oogenesis by causing mitochondria disorder in neonates. Environ Toxicol Pharmacol. 2023 Sep;102:104239. doi: 10.1016/j.etap.2023.104239.
6. Ma Yidan#, Mu Xinyi#, Gao Rufei, Zhang Yan, Geng Yanqing, Chen Xuemei, Yin Xin, Li Fangfang, He Junlin*. Maternal exposure to dibutyl phthalate regulates MSH6 crotonylation to impair homologous recombination in fetal oocytes. J Hazard Mater. 2023 Aug 5;455:131540. doi: 10.1016/j.jhazmat.2023.131540.
7. Qiqi Liu#, Junlin He, Xuemei Chen, Yi Hong, Fangfang Li, Yanqing Geng, Yan Zhang, Lamptey Jones, Zhuxiu Chen, Fangfei Liu, Yingxiong Wang, Xinyi Mu*. Fetal exposure of Aristolochic Acid I undermines ovarian reserve by disturbing primordial folliculogenesis. Ecotoxicol Environ Saf. 2022. doi: 10.1016/j.ecoenv.2022.113480.
8. Mu Xinyi#, Tu Zhihan, Chen Xuemei, Hong Yi, Geng Yanqing, Zhang Yan, Ji Xingduo, Liu Taihang, Wang Yingxiong, He Junlin*, In Utero Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice. Frontiers in cell and developmental biology. 2021, 9: 1352. doi: 10.3389/fcell.2021.669732.
9. Yi Hong#, Xinyi Mu#, Xingduo Ji, Xuemei Chen, Yanqing Geng, Yan Zhang, Qiqi Liu, Fangfang Li, Yingxiong Wang, Junlin He*, In-utero exposure to HT-2 toxin affects meiotic progression and early oogenesis in foetal oocytes by increasing oxidative stress. Environmental Pollution. 2021, 279:116917. doi: 10.1016/j.envpol.2021.116917
10. Tu Zhihan#, Mu Xinyi#, Chen Xuemei, Geng Yanqing, Zhang Yan, Li Qingying, Gao Rufei, Liu Taihang, Wang Yingxiong, He Junlin*, Dibutyl phthalate exposure disrupts the progression of meiotic prophase I by interfering with homologous recombination in fetal mouse oocytes. Environmental Pollution.2019, 252: 388-398. doi: 10.1016/j.envpol.2019.05.107
11. Tu Zhihan#, Mu Xinyi#, Li Qingying, Gao Rufei, Zhang Yan, Chen Xuemei, Geng Yanqing, Wang Yingxiong, He Junlin*, Autophagy participates in cyst breakdown and primordial folliculogenesis by reducing ROS levels in perinatal mouse ovaries. J Cell Physiol. 2019, 234(5):6125-6135. doi: 10.1002/jcp.27367.
12. Zhang Yan#, Mu Xinyi#, Gao Rufei, Geng Yanqing, Liu Xueqing, Chen Xuemei, Wang Yuheng, Ding Yubin, Wang Yingxiong, He Junlin*, Foetal-neonatal exposure of Di (2-ethylhexyl) phthalate disrupts ovarian development in mice by inducing autophagy. J Hazard Mater. 2018, 15;358:101-112. doi: 10.1016/j.jhazmat.2018.06.042
13. Mu Xinyi#, Wen Jia #, Chen Qian, Wang Zhengpin, Wang Yijing, Guo Meng, Yang Yi, Xu JinRui, Wei Zhiqing, Xia Guoliang, Yang Mengye, Wang Chao*, Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice. Biology Open (2018) 7, bio035626. doi: 10.1242/bio.035626
14. Mu Xinyi# , Liao Xinggui, Chen Xuemei, Li Yanli, Wang Meirong, Shen Cha, Zhang Xue, Wang Yingxiong, Liu Xueqing, He Junlin*, DEHP exposure impairs mouse oocyte cyst breakdown and primordial follicle assembly through estrogen receptor-dependent and independent mechanisms. J Hazard Mater, 2015, 298：232-240. doi: 10.1016/j.jhazmat.2015.05.052
15. Mu Xinyi#, Wen Jing, Guo Meng, Wang Jianwei, Li Ge, Wang Zhengpin, Wang Yijing, Teng Zhen, Cui Yan, Xia Guoliang*, Retinoic acid derived from the fetal ovary initiates meiosis in mouse germ cells., Journal of Cellular Physiology, 2013, 228（3）：627-639. doi: 10.1002/jcp.24172
16. Zhu Jiahong# ,Mu Xinyi#, Zeng Jin, Xu Chunyan, Liu Jun, Zhang Mengsi, Li Chengpeng, Chen Jie, Li Tinyu, Wang Yaping*, Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. PLos One, 2014, 9（6）：e101291-e101291. doi: 10.1371/journal.pone.0101291
17. Xinyi Mu#, Yanyan Zhang, Jing Li, Jieyu Xia, Xiongbin Chen, Pengwei Jing, Xiaoying Song, Lu Wang, Yaping Wang*, Angelica Sinensis Polysaccharide prevents hematopoietic stem cells senescence in Dgalactose- induced aging mouse model., Stem cell international. 2017:3508907. doi: 10.1155/2017/3508907.
