个人简介
徐伟，特聘教授，博士生导师。2013年获北京大学药学学士学位，2015年获北京大学化学生物学硕士学位，2015年-2022年在美国约翰霍普金斯大学Jonathan Powell教授课题组进行博士及博士后研究。2024年2月加入重庆医科大学免疫创新与转化研究院。主要研究方向为细胞代谢对免疫细胞功能与分化的调控。取得的研究成果作为第一作者在Nature、Acta Pharmaceutica Sinica B、Cell Reports发表论文3篇；受邀以第一作者在Cell Metabolism发表preview 1篇；作为共同作者在Molecular Cell、The Journal of Clinical Investigation、The Journal of Immunology等杂志发表研究论文12篇。
教育背景及工作经历
2009.09-2013.07 北京大学药学专业，理学学士
2010.09-2013.07 北京大学经济学专业，经济学学士（双学位）
2013.09-2015.07 北京大学化学生物学专业，理学硕士
2015.08-2021.04 约翰霍普金斯大学药理学与分子科学专业，博士
2021.04-2022.01 约翰霍普金斯大学肿瘤学系，博士后
2022.03-2024.02 天科雅生物科技有限公司，研发员
2024.02-至今 重庆医科大学科技创新中心，特聘教授
科研项目
国家自然科学基金青年科学基金项目，30万元，2025.01.01-2027.12.31，主持
代表性论文
1. Wei Xu, Chirag H. Patel, Jesse Alt, Liang Zhao, Im-Hong Sun, Min-Hee Oh, Im-Meng Sun, Jiayu Wen, Richard L. Blosser, Ada J. Tam, Jonathan D. Powell. GOT1 constrains TH17 cell and promotes Treg cell differentiation. Nature. 2023, 614: E1-E11.
2. Wei Xu, Chirag H. Patel, Liang Zhao, Im-Hong Sun, Min-Hee Oh, Im-Meng Sun, Rachel Helms, Jiayu Wen, Jonathan D. Powell. GOT1 regulates CD8+ effector and memory T cell generation. Cell Reports. 2023, 42 (1): 11987.
3. Wei Xu, Jonathan D. Powell. Peeking under the hood of naive T cells. Cell Metabolism. 2018, 28 (6): 801-802.
4. Wei Xu, Boehm Garth, Qiang Zheng. Factors to consider in developing individual pharmaceutical product quality risk profiles useful to government procurement agencies. Acta Pharmaceutica Sinica B. 2016, 6 (1): 79-92.
5. Xiaoqing Zheng, Wei Xu, Ruoxuan Sun, Hanwei Yin, Chaoran Dong, Huihui Zeng. Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells. Chemico-Biological Interactions. 2017, 275: 74-85.
6. Zan Chen, Hanjie Jiang, Wei Xu, Xiaoguang Li, Daniel R. Dempsey, Xiangbin Zhang, Peter Devreotes, Cynthia Wolberger, L. Mario Amzel, Sandra B. Gabelli, Philip A. Cole. A tunable brake for HECT ubiquitin ligases. Molecular Cell. 2017, 66 (3): 345-357.
7. Chirag H. Patel, Emily B. Heikamp, Wei Xu, Im-Hong Sun, Min-Hee Oh, Im-Meng Sun, Jiayu Wen, Ada J. Tam, Richard L. Blosser, Jonathan D. Powell. mTORC2 regulates CD8+ effector and memory T cell differentiation through serum and glucocorticoid kinase 1. The Journal of Immunology. 2022, 209 (12): 2287-2291.
8. Beth E Zucconi, Birgit Luef, Wei Xu, Ryan A. Henry, Ilana M. Nodelman, Gregory D. Bowman, Andrew J. Andrews, Philip A. Cole. Modulation of p300/CBP acetylation of nucleosomes by bromodomain ligand I-CBP112. Biochemistry. 2016, 5 (27): 3727-3734.
9. Min-Hee Oh, Im-Hong Sun, Liang Zhao, Robert D. Leone, Im-Meng Sun, Wei Xu, Samuel L. Collins, Ada J. Tam, Richard L. Blosser, Chirag H. Patel, Judson M. Englert, Matthew L. Arwood, Jiayu Wen, Yee Chan-Li, Lukáš Tenora, Pavel Majer, Rana Rais, Barbara S. Slusher, Maureen R. Horton, Jonathan D. Powell. Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells. The Journal of Clinical Investigation. 2020, 130 (7): 3865-3884.
10. Im-Hong Sun, Min-Hee Oh, Liang Zhao, Chirag H. Patel, Matthew L. Arwood, Wei Xu, Ada J. Tam, Richard L. Blosser, Jiayu Wen, Jonathan D. Powell. mTOR complex 1 signaling regulates the generation and function of central and effector Foxp3+ regulatory T cells. The Journal of Immunology. 2018, 201 (2): 481-492.
