个人简介:
丁陈波,医学博士,特聘教授,博士生导师,专注于RNA表观遗传修饰影响免疫细胞功能稳态和衰老在肠道粘膜免疫、肠道神经免疫中的调控作用,以第一作者和通讯作者(含共同)在Nature Aging、PNAS、Science Advances、Cancer Letters、Cell Death & Disease、Journal of Experimental & Clinical Cancer Research等国际权威学术期刊发表近20篇论文。主持、参与国家自然科学基金重点专项、面上项目和青年项目等。兼任《Cancer Cell International》杂志副主编,Science Advances、Nature Communications、Advanced Science、Journal of Experimental & Clinical Cancer Research、Cellular and Molecular Life Sciences等杂志特约审稿人。
教育背景及科研工作经历
2024.9-至今,重庆医科大学 免疫创新与转化研究院 特聘教授
2024.1-2024.8 上海交通大学医学院-上海市免疫学研究所 副研究员
2023.3-2023.12 上海交通大学医学院-上海市免疫学研究所 助理研究员
2021.1-2023.2 上海交通大学医学院-耶鲁大学医学院免疫代谢研究院 博士后 助理研究员 导师:李华兵教授
2016.9-2020.12 东南大学医学院 博士 临床检验诊断学
2018.9-2020.10 美国耶鲁大学医学院 国家公派博士联合培养 免疫生物学
2013.9-2016.6 遵义医科大学 硕士 免疫学
2006.9-2009.7 湖北中医药大学 学士 医学检验技术
主持科研项目
1. 国家自然科学基金委员会青年项目(82202017)
2. 上海交通大学医学院新进青年教师启动计划(KJ3-0221-22-6338)
3. 中国博士后面上项目(2021M702160)
4. 重庆医科大学高层次引进人才科研启动项目(R2062)
代表性论文(#第一作者;*通讯作者)
[1] Wang X#, Ding C*, Li HB*. The crosstalk between enteric neuron system and immune system in intestinal development, homeostasis and diseases. Science China Life Sciences. 2024, 67(1):41-50.
[2] Ding C#, Yu Z#, Sefik E#, Zhou J#, Kaffe E, Wang G, Li B, Flavell RA, Hu W, Ye Y, Li HB*; A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in aging liver. Nature Aging. 2023, 3(7):813-828.
(Highlighted by: News & Views: Ma Y. & Cao H. Nature Aging, 2023. 3, 760–761; Research Highlight: Hguyen H.T. & Batista P.J. Science China Life Sciences. 2023. 66)
[3] Ding C#, Xu H#, Yu Z#, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W*, Flavell RA*, Li HB*. RNA m6A demethylase ALKBH5 regulates the development of γδ T cells. PNAS. 2022, 119(33):e2203318119.
[4] Zhang T#, Ding C#,*, Chen H#, Zhao J, Chen Z, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M*, Flavell RA*, Li HB*. m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB-mediated antiapoptotic pathway. Science Advances. 2022, 8(12):eabl5723.
[5] Yang L#, Ding C#,*, Tang W, Yang T, Liu M, Wu H, Wen K, Yao X, Feng J*, Luo J*. INPP4B exerts a dual function in the stemness of colorectal cancer stem-like cells through regulating Sox2 and Nanog expression. Carcinogenesis. 2020, 41(1):78-90.
[6] Ding C*, Tang W, Wu H, Fan X, Luo J, Feng J, Wen K, Wu G*. The PEAK1-PPP1R12B axis inhibits tumor growth and metastasis by regulating Grb2/PI3K/Akt signalling in colorectal cancer. Cancer Letters. 2019, 442:383-395.
[7] Tang W#, Yang L#, Yang T#, Liu M, Zhou Y, Lin J, Wang K*, Ding C*. INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma. OncoTargets and Therapy. 2019, 12:3491-3507.
[8] Ding C#,*, Tang W#, Fan X, Wang X, Wu H, Xu H, Xu W, Gao W, Wu G*. Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling. Cell Death & Disease. 2018, 9(8):802.
[9] Ding C, Luo J*, Fan X, Li L, Li S, Wen K, Feng J*, Wu G*. Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels. Journal of Experimental & Clinical Cancer Research. 2017, 36(1):56.
[10] Ding C#, Luo J#, Li L, Li S, Yang L, Pan H, Liu Q, Qin H, Chen C, Feng J*. Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer. Journal of Experimental & Clinical Cancer Research. 2016, 35:5.