个人简介
教授、博士生导师，重庆英才青年拔尖人才。2022年加入重庆医科大学。担任重庆市生物化学与分子生物学会理事。主持国家自然科学基金项目2项，省部级科研项目2项，累计科研经费近300万元。在Nature Cell Biology，Nuclear Acid Research，Protein&Cell等发表学术文章13篇。围绕“蛋白质液-液相分离在维持染色质结构和基因表达调控的功能及分子机制”这一前沿科学问题进行研究，以转录因子、染色质结合蛋白等为切入点，揭示染色质高级结构和基因表达调控的分子机制。
教育背景及工作经历
2009-2013 四川大学 生物工程专业 学士
2013-2018 北京大学 生物物理专业 博士
2018-2020 北京大学生物医学前沿创新中心 博士后
2021-2022 北京安贞医院心肺研究所 助理研究员
2022-至今 重庆医科大学基础医学院生化与分子生物学教研室 教授
学术兼职
2023-至今 重庆市生物化学与分子生物学会理事。
奖项及荣誉
2013年 四川省优秀毕业生
2018年 北京市优秀毕业生
主持科研项目
1. 国家自然科学基金委，面上项目，32270737, AHDC1相变在夏氏综合征中的致病机制研究,54万，2023-2026
2. 国家自然科学基金委，青年项目，31900898, 细胞核内actin聚合促进聚合酶RNA Pol II相分离调控转录过程的机制研究,24万，2020-2022
3. 重庆市自然科学基金，2023NSCQ-MSX0112，夏氏综合征致病机制研究，面上项目，10万，2023-2026
4 第十二届中国博士后基金特别资助，2019T120013, 细胞核内actin聚合促进聚合酶RNA Pol II相分离调控转录过程的机制研究,18万，2019-2020
5 第六十六届中国博士后基金面上项目资助，2019M660004,热休克过程中转录因子HSF1的相分离促进转录过程研究，12万，2019-2020
代表性论文、专利
1. Hongchen Zhang#, Shipeng Shao#*, Yong Zeng, Xiaotian Wang, Yizhi Qin, Qiunan Ren, Shengqi Xiang, Yuxin Wang, Junyu Xiao, Yujie Sun*. (2022). Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock. Nature Cell Biology, 2022, 24, 340–352.
2. Shipeng Shao, Weiwei Zhang, Huan Hu, Boxin Xue, Jinshan Qin, Chaoying Sun, Yuao Sun, Wensheng Wei, and Yujie Sun, Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 system. Nucleic acids research, 2016. 44(9): p. e86-e86.
3. Lei Chang#, Mengfan Li#, Shipeng Shao#, Boxin Xue, Yingping Hou, Ruifeng Li, Cheng Li, and Yujie Sun, Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells. Protein & cell, 2020. p. 1-23.
4. Shipeng Shao, Lei Chang, Yuao Sun, Yingping Hou, Xiaoying Fan, and Yujie Sun, Multiplexed sgRNA expression allows versatile single nonrepetitive DNA labeling and endogenous gene regulation. ACS synthetic biology, 2017. 7(1): p. 176-186.
5. Shipeng Shao, Hongchen Zhang, Yong Zeng, Yongliang Li, Chaoying Sun, Yujie Sun, TagBiFC technique allows long-term single-molecule tracking of protein-protein interactions in living cells. Communications biology, 2021. 4(1): p. 1-14.
6. Shipeng Shao, Boxin Xue, and Yujie Sun, Intranucleus single-molecule imaging in living cells. Biophysical journal, 2018. 115 (2), p. 181-189.
7. Shipeng Shao, Lei Chang, Yingping Hou, and Yujie Sun, Illuminating the structure and dynamics of chromatin by fluorescence labeling. Frontiers in Biology, 2017. 12(4): p. 241-257.
8. Hongchen Zhang, Shipeng Shao*, Yujie Sun*. (2022). Characterization of liquid-liquid phase separation using super-resolution and single-molecule imaging. Biophysics Reports, 2022, 7, 1-12.（
9. Yuan Wang, Chunlei Zhang, Wenzhong Yang, Shipeng Shao, Xinmin Xu, Yujie Sun, Pilong Li, Ling Liang, Congying Wu, LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force. Developmental Cell, 56 (9), 1313-1325. e7.
10. Mian Wei, Xiaoying Fan, Miao Ding, Ruifeng Li, Shipeng Shao, Yingping Hou, Shaoshuai Meng, Fuchou Tang, Cheng Li, Yujie Sun, Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering. Science Advances, 6 (16), eaay6515.
11. Yongliang Li, Shipeng Shao, Xiao Xu, Xiaodong Su, Yujie Sun, and Shicheng Wei, MapZ Forms a Stable Ring Structure That Acts as a Nanotrack for FtsZ Treadmilling in Streptococcus Mutans. ACS nano, 2018.
12. Lei Chang, Gang Sheng, Yiwen Zhang, Shipeng Shao, Yanli Wang, Yujie Sun, AgoFISH: cost-effective in situ labelling of genomic loci based on DNA-guided dTtAgo protein. Nanoscale Horizons, 4 (4), 918-923.
13. Xue Boxin, Zhou Caiwei, Qin Yizhi, Li Yongzheng, Sun Yuao, Chang Lei, Shao Shipeng, Li Yongliang, Zhang Mengling, Sun Chaoying, He Renxi, Peter Su Qian, Sun Yujie, PN-ImTLSM facilitates high-throughput low background single-molecule localization microscopy deep in the cell. Biophysics Reports, 7 (4), 313-325.
