个人简介
副教授、硕士生导师、医学博士。2011年加入重庆医科大学，任基础医学院生物化学与分子生物学教研室副主任。主持国家自然科学基金项目1项，省部级科研项目2项，累计科研经费近40万元。从事肺癌、卵巢癌等实体瘤标志物的筛选和肿瘤发生演进机制的研究，目前主要开展tsRNA（tRNA-derived small RNA）和rsRNA（rRNA-derived small RNA）的肿瘤相关性研究。以第一作者/通讯作者在学术刊物Nature Cell Biology, Cancer Letters, Proteomics, Genes等发表学术文章10余篇。
教育背景及工作经历
2002-2006 南京大学生物科学专业 学士
2006-2011 北京协和医学院肿瘤学专业 博士
2011-2016 重庆医科大学基础医学院生物化学与分子生物学教研室 讲师
2019-2020 美国加州大学河滨分校医学院 访问学者
2016-至今 重庆医科大学基础医学院生物化学与分子生物学教研室 副教授
学术兼职
2023-至今 重庆市生物化学与分子生物学学会理事
主持科研项目
2013年，国家自然科学基金青年科学基金项目，NID1通过EMT促进卵巢癌侵袭转移的分子机制研究(81302263)
2021年，重庆市教育委员会科学技术研究项目，5’-tsRNA-Glu在肺癌发生发展中的作用及其临床意义(KJQN202100403)
2022年，重庆市自然科学基金面上项目，ALKBH4通过5’-tsRNAGlu调控肺癌细胞翻译效率的分子机制研究(CSTB2022NSCQ-MSX0123)
代表性论文、专利
1. Dandan Xu#, Deqian Qiao#, Yunlong Lei, Chundong Zhang, Youquan Bu*, Ying Zhang*. Transfer RNA-derived small RNAs (tsRNAs): Versatile regulators in cancer. Cancer Letters. 2022. 546: 215842.
2. Junchao Shi#, Yunfang Zhang#, Dongmei Tan#, Xudong Zhang#, Menghong Yan#, Ying Zhang#, Reuben Franklin#, Marta Shahbazi, Kirsty Machkinlay, Shichao Liu, Bernhard Kuhle, Emma R. James, Liwen Zhang, Yongchun Qu, Qiwei Zhai, Wenxin Zhao, Linlin Zhao, Changcheng Zhou, Weifeng Gu, Jernej Murn, Jingtao Guo, Douglas T. Carrell, Yinsheng Wang, Xuemei Chen, Bradley R. Cairns, Xiang-lei Yang, Paul Shimmel, Magdalena Zernicka-Goetz, Sihem Cheloufi, Ying Zhang*, Tong Zhou*, Qi Chen*. PANDORA-seq: expanding the small RNA repertoire by overcoming RNA modifications. Nat Cell Biol. 2021. 23(4): 424-436.
3. Deqian Qiao#, Yiling Liu#, Yunlong Lei, Chundong Zhang, Youquan Bu, Yishu Tang*, Ying Zhang*. rRNA-Derived Small RNA rsRNA-28S Regulates the Chemoresistance of Prostate Cancer Cells By Targeting PTGIS. FRONTIERS IN BIOSCIENCE-LANDMARK. 2023. 28 (5).
4. Yiyun Sun#, Dandan Xu#, Chungdong Zhang, Yitao Wang, Lian Zhang, Deqian Qiao, Youquan Bu, Ying Zhang. HEDGEHOG/GLI modulates the PRR11-SKA2 bidirectional transcription unit in lung squamous cell carcinomas. Genes. 2021. 12 (1): 120.
5. Ya Zhou#, Yuanyuan Zhu#, Xiaoyan Fan#, Chundong Zhang, Yitao Wang, Lian Zhang, Huan Zhang, Tao Wen, Kaina Zhang, Xiao Huo, Xue Jiang, Youquan Bu, Ying Zhang*. NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells. 2017. Oncotarget. 2017, 8(20): 33110-33121.
6. Yitao Wang#, Ying Zhang#, Chundong Zhang#, Huali Weng#, Yi Li, Wei Cai, Mengyu Xie, Yinjiang Long, Qing Ai, Zhu Liu, Gang Du, Sen Wang, Yulong Niu, Fangzhou Song, Toshinori Ozaki, Youquan Bu*. The gene pair PRR11 and SKA2 shares a NF-Y-regulated bidirectional promoter and contributes to lung cancer development. Biochim Biophys Acta. 2015, 1849 (9): 1133-1144.
7. Ying Zhang#, Zaixing Zhang, Lei Yang, Bin Xu, Weihua Li, Pingzhang Tang, Zongmin Zhang, Naijun Han, Yanning Gao, Shujun Cheng, Ting Xiao*. Identification of human tissue kallikrein 6 as a potential marker of laryngeal cancer based on the relevant secretory/releasing protein database. Dis Markers. 2014, 594093. Doi: 10.1155/2014/594093.
8. Ying Zhang#, Bin Xu, Yu Liu, Hongwen Yao, Nenan Lu, Bin Li, Jia Gao, Suping Guo, Naijun Han, Jun Qi, Kaitai Zhang, Shujun Cheng, Hongxia Wang, Xuemin Zhang, Ting Xiao*, Lingying Wu*, Yanning Gao*. The ovarian cancer-derived secretory/releasing proteome: a repertoire of tumor markers. Proteomics. 2012, 12: 1883-1891.
