个人简介

  京都大学医学博士，2014-2022年间在京都大学iPS细胞研究所从事研究员工作。从事前沿生物技术开发、诱导型多能干细胞（iPSCs）的特定组织器官分化以及iPSCs的临床应用方向的研究。作为负责人承担3项日本国家级科研基金项目,作为团队骨干参与2项日本再生医疗重点专项基金。以通讯作者身份在 Advanced Science, Stem Cell Reports 等干细胞领域知名期刊发表论文多篇，获得并转化多项国际发明专利。

研究方向

1. 干细胞定向分化体系的构建和体外疾病模型的开发。

2. 干细胞分化过程中细胞命运调控的机制研究。

3. 组织器官再生修复以及再生医学的临床应用。

获奖及荣誉

1. Excellent Poster Award. The 39th MBSJ 2016.

2. Best Oral Presentation Award. CiRA Retreat 2017.

3. Best Oral Presentation Award. CiRA Retreat 2019.

4. CiRA Encouragement Award, 2021.

代表性论文

1. Guo Q, Chen J, Bu Q, Zhang J, Ruan M, Chen X, Zhao M, Tu X, Zhao C. Establishing stable and highly osteogenic hiPSC-derived MSCs for 3D-printed bone graft through microenvironment modulation by CHIR99021-treated osteocytes. Materials Today Bio. June 2024.

2. Zhao M*, Taniguchi Y, Shimono C, Jonouchi T, Cheng Y, Shimizu Y, Nalbandian M, Yamamoto T, Nakagawa M, Sekiguchi K, and Sakurai H*. Heparan sulfate chain-conjugated laminin-E8 fragments advance paraxial mesodermal differentiation followed by high myogenic induction from hiPSCs. Advanced Science. *Correspondence author. April 2024.

3. Nalbandian M, Zhao M, Kato H, Jonouchi T, Nakajima-Koyama M, Yamamoto T, Sakurai H. Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation. Life Science Alliance. Vol.5, No.8. April 2022.

4. Takenaka-Ninagawa N*, Kima J, Zhao M, Sato M, Jonouchi T, Goto M, Yoshioka C, Ikeda R, Harada A, Sato T, Ikeya M, Uezumi A, Nakatani M, Noguchi S, Sakurai H*. Collagen-VI supplementation by cell transplantation improves muscle regeneration in Ullrich congenital muscular dystrophy model mice. Stem Cell Research & Therapy. Vol. 12, 446. August 2021.

5. Nalbandian M, Zhao M*, Sasaki-Honda M, Jonouchi T, Lucena-Cacace A, Mizusawa T, Yasuda M, Yoshida Y, Hotta A, Sakurai H*. Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy. Stem Cell Reports. Vol.16, pp 883-898. April 2021 *Correspondence author.

6. Zhao M*, Tazumi A, Takayama S, Takenaka-Ninagawa M, Nalbandian M, Nagai M, Nakamura Y, Nakasa M, Watanabe A, Ikeya M, Hotta A, Ito Y, Sato T, and Sakurai H*. Induced Fetal Human Muscle Stem Cells with High Therapeutic Potential in a Mouse Muscular Dystrophy Model. Stem Cell Reports. Vol.15, pp 80-94. July 2020 *Correspondence author.

7. Zhao M, Shoji E, Sakurai H. In Vitro Evaluation of Exon Skipping in Disease-Specific iPSC-Derived Myocytes. Method in Molecular Biology. Vol. 1828, pp 173-189. 2018. Book series.

8. Gumbilai V, Ebihara K, Aizawa-Abe M, Ebihara C, Zhao M, Yamamoto Y, Mashimo T, Hosoda K, Serikawa T, Nakao K. Fat Mass Reduction with Adipocyte Hypertrophy and Insulin Resistance in Heterozygous PPARγ Mutant Rats. Diabetes. Vol. 65, No. 10, pp. 2954-2965; Oct 2016.

9. Cai X, Fang C, Hayashi S, Hao S, Zhao M, Tsutsui H, Nishiguchi S, Sheng J. Pu-erh tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice. Journal of Gastroenterology. Vol. 51, No. 8, pp. 819-829; Aug 2016.

10. Ebihara C, Ebihara K, Aizawa-Abe M, Mashimo T, Tomita T, Zhao M, Gumbilai V, Kusakabe T, Yamamoto Y, Aotani D, Yamamoto-Kataoka S, Sakai T, Hosoda K, Serikawa T, Nakao K. Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis. Human Molecular Genetics. Vol. 24, No. 15, pp. 4238-4249; August 2015.

11. Zhao M, Li Y, Wang J, Ebihara K, Rong X, Hosoda K, Tomita T, Nakao K. Azilsartan treatment improves insulin sensitivity in obese spontaneously hypertensive Koletsky rats. Diabetes, Obesity and Metabolism. Vol. 13, No. 12, pp. 1123-1129, December 2011.

12. Rong X, Li Y, Ebihara K, Zhao M, Naowaboot J, Kusakabe T, Kuwahara K, Murray M, Nakao K. Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice. Diabetologia. Vol. 53, No. 8, pp. 1727-1731, August 2010.