教研室简介（历史沿革，现状简介）
重庆医科大学生物学（现为细胞生物学及遗传学）教研室组建于1956年，人员均为从上海医学院内迁支援的老中青教师和教辅人员。教研室负责人是我国著名生物学家陈世騠教授。
细胞生物学及遗传学教研室涵盖基础医学院生物学一级学科下两门二级学科：细胞生物学和遗传学。于2000年取得遗传学硕士学位授予权，2005年取得得细胞生物学硕士学位授予权，2021年取得生物学一级学科博士学位授予权，开展以教学、科研和人才培养为重心的各项工作。
学科现有全职教师20人，其中教授9人，副教授4人，副研究员3人，讲师4人。其中上海市曙光学者，上海市浦江人才，巴渝学者讲座讲授，重庆市首席专家工作室领衔专家，国家重大科学研究计划（973）首席科学家，教育部长江学者特聘教授，国家重大科学研究计划（973）首席科学家1人，教育部“新世纪优秀人才”、重庆市“高等学校优秀人才”1人、重庆市“巴渝学者”计划青年学者1人、重庆市学术技术带头人后备人选1人。
师资队伍（按职称分类写）
教 授：文波、郭风劲、陈俊霞、张政、张军、向云龙、任春光、董志伟、朱勇。
副教授：程志、孙艳、崔艳艳、郭玉萍
副研究员：乔梁峻、谢万华、陈恩祥
讲师：李小丽、任肃霞、范梦恬、范思佳。
教学工作：课程，教材建设，教学课题简介，人才培养（本科生研究生）
1.课程：承担本科生课程：《细胞生物学》（适用于临床医学八年制）理论及实验、《医学细胞生物学》（适用于临床医学卓越班及其他临床医学等相关专业）理论及实验、《医学细胞生物学（英文授课）》（适用于临床医学留学生班）理论及实验、《医学生物学》理论及实验，年均为本科生授课理论标准学时约2000，实验标准学时约1600；承担研究生课程：《医学细胞生物学及遗传学现代研究》理论（适用于各专业方向硕士研究生）理论，年均为研究生授课理论标准学时36，其中高级职称理论授课学时达100%。
2.教学改革及成果方面：
(1)“十四五”普通高等教育本科规划教材，《医学细胞生物学》（科学出版社），陈元晓、陈俊霞主编 ，2015年;
(2)“十四五”普通高等教育本科规划教材，《医学遗传学》（科学出版社），马用信、郭风劲主编，2020年；
(3)“5+3”医学整合课程教材《分子与细胞》，人民卫生出版社，王应雄主编，2016年；
(4)《医学细胞生物学与遗传学学习指导》(科学出版社），郭风劲主编；
(5)普通高等学校“十四五”规划医学实验示范中心新形态教材-《显微形态学实验教程》（人民卫生出版社）;
(6)“十三五”普通高等教育本科国家级规划教材，《细胞生物学》第三版，编委，2015，人民卫生出版社；
（7）普通高等教育“十三五”、“十二五”规划教材，《医学细胞生物学》，编委，科学出版社。
3.人才培养
近三年招收硕士研究生36人，毕业17人；招收博士研究生18人，毕业6人；本科生（入科室实习）约6人/年，均顺利完成毕业答辩。
4.科学研究：定位，研究方向，代表性团队及论文
本学科形成了细胞核超微结构与疾病发生、骨生物学、胚胎发育与表观遗传调控、肾脏损伤的分子机制研究和肺部炎症疾病等几个主要研究方向。
（1）细胞核超微结构与疾病发生（文波教授团队）
团队以第一或通讯作者在Nature、Nature Genetics、Molecular Cell、Genome Research等期刊发表研究型学术论文48篇，被引用>7500次。课题组围绕“染色质高级结构的功能及分子机制”这一前沿科学问题进行研究，以核基质（Nuclear Matrix）、核体（Nuclear Bodies）等细胞核超微环境为切入点，揭示了多个新的染色质高级结构调控分子及作用机制。近五年主持国家重大科学研究计划、国家基金委重点项目等国家级科研项目4项，总经费超过3400万元。
代表性论文：
1. Huo X, Ji L, Zhang Y, Lv P, Cao X, Wang Q, Yan Z, Dong S, Du D, Zhang F, Wei G, Liu Y, Wen B*. The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation. Molecular Cell. 2020 Jan 16;77(2):368-383.
2. Fan H#, Lv P#, Huo X, Wu J, Wang Q, Cheng L, Liu Y, Tang QQ, Zhang L, Zhang F, Zheng X, Wu H, Wen B*. The nuclear matrix protein HNRNPU maintains 3D genome architecture globally in mouse hepatocytes. Genome Research. 2018 Feb;28(2):192-202.
3. Zhang Y#, Cao X#, Gao Z#, Ma X#, Wang Q, Xu X, Cai X, Zhang Y, Zhang Z, Wei G*,Wen B*. MATR3-antisense LINE1 RNA meshwork scaffolds higher-order chromatin organization. EMBO Rep. 2023 Aug 3;24(8):e57550.
4. Ming H#, Wang Q#, Zhang Y, Ji L, Cheng L, Huo X, Yan Z, Dang Y and Wen B*. The nuclear bodies formed by histone demethylase KDM7A. Protein & Cell. 2021 Apr;12(4):297-304.
5. Wang Y#, Hong Q, Xia Y#, Zhang Z*, Wen B*. The Lysine Demethylase KDM7A Regulates Immediate Early Genes in Neurons. Advanced Science. 2023 Aug: 10(28):e2301367.
6. Sun Z#, Zhu M#, Lv P, Cheng L, Wang Q, Tian P, Yan Z, Wen B*. The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway. Stem Cell Reports. 2018. 11(3):741-755.
7. Hu S#, Lv P#, Yan Z, Wen B*. Disruption of nuclear speckles reduces chromatin interactions in active compartments. Epigenetics & Chromatin. 2019 Jul 17;12(1):43.
8. Wen B, Wu H, Shinkai Y, Irizarry R and Feinberg AP*. Large histone H3 lysine-9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nature Genetics. 2009. 41: 246-50 (Cover story).
9. Doi A#, Park IH#, Wen B#, Murakami P, Aryee M, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J, Schlaeger T, Daley GQ and Feinberg AP*. Differential methylation of tissue- and cancer specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nature Genetics. 2009 41(12):1350-3.
10. Wen B*, Xie X, Gao S, Li H, Shi H, Song X, Qian T, Xiao C, Jin J, Su B, Lu D, Chakraborty R, Jin L*. Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans. Am. J. Hum. Genet. 2004. 74: 856-65.
（2）骨生物学（郭风劲教授团队）
团队围绕骨/软骨发育与遗传疾病、骨与关节功能损伤与重塑机制及药物研发开展一系列研究工作，以第一、通讯作者在学术刊物Nature Communications、ACS NANO、Experimental & Molecular Medicine、Arthritis Rheumatism、J Adv. Res等发表研究论著50余篇；获得重庆市自然科学奖三等奖（第一完成人）；获得国家发明专利2项；作为主编、副主编、编委完成国家级规划教材和专著撰写16部。团队成员主持国家自然科学基金项目8项，教育部“新世纪优秀人才”资助计划、教育部海外留学回国人员资助计划、重庆市等各类省部级项目二十余项。
代表性论文（#第一作者，*通讯作者）：
1. Nana Geng, Mengtian Fan, Biao Kuang,Fengmei Zhang, Menglin Xian,Lin Deng, Cheng Chen, Yiming Pan, Jianqiang Chen, Naibo Feng, Li Liang,Yuanlan Ye, Kaiwen Liu, Xiaoli Li, Yu Du, Fengjin Guo*.10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically. Nature Communications. 2024 Sep 4;15(1):7712.
2. Li Liang#, Fengmei Zhang#, Naibo Feng#, Biao Kuang, Mengtian Fan, Cheng Chen, Yiming Pan, Pengfei Zhou, Nana Geng, Xingyue Li, Menglin Xian, Lin Deng, Xiaoli Li, Liang Kuang, Fengtao Luo, Qiaoyan Tan, Yangli Xie, Fengjin Guo*. IRE1α protects against osteoarthritis by regulating progranulin dependent XBP1 splicing and collagen homeostasis. Experimental & Molecular Medicine, 2023 Nov; 55(11):2376-2389.
3. Nana Geng, Menglin Xian, Lin Deng, Biao Kuang, Yiming Pan, Kaiwen Liu, Yuanlan Ye, Mengtian Fan, Zhixun Bai, Fengjin Guo*. Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis. Journal of Orthopaedic Translation, 2024 Jun; 47: 50-62.
4. Naibo Feng#, Yuanlan Ye#, Yiming Pan#, Biao Kuang, Yu Du, Nana Geng, Cheng Chen, Kaiwen Liu, Li Liang, Menglin Xian, Yuyou Yang, Xingyue Li, Lin Deng, Fengmei Zhang, Liang Kuang, Mengtian Fan, Yangli Xie, Fengjin Guo*. The circUbqln1, regulated by XBP1s, interplays with 14-3-3ζ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism. J Adv Res..2024 Jan 12: S2090-1232(24)00007-9.
5. Naibo Feng#, Li Liang, Mengtian Fan, Yu Du, Cheng Chen, Rong Jiang, Dongsheng Yu, Yuyou Yang, Mengying Zhang, Lin Deng, Xingyue Li, Nana Geng, Menglin Xian, Qizhong Qin, Xiaoli Li, Qiaoyan Tan, Fengtao Luo, Fangzhou Song, Huabing Qi, Yangli Xie, Fengjin Guo*. Treating Autoimmune Inflammatory Diseases with an siERN1-Nanoprodrug That Mediates Macrophage Polarization and Blocks Toll-like Receptor Signaling. ACS Nano. 2021 Oct 26;15(10): 15874-15891.
6. Mengtian Fan#, Nana Geng#, Xingyue Li#, Danyang Yin,Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi,Qiaoyan Tan , Yangli Xie, Fengjin Guo*.IRE1a regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization. Genes Dis. 2022 Dec 29;11(1):464-478.
7.Xiaoli Li#, Yuyou Yang, Li Liang, Mengtian Fan, Xingyue Li, Naibo Feng, Yiming Pan, Qiaoyan Tan, Qingbo Xu, Yangli Xie, Fengjin Guo*. Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA mRNA. International Journal of Biological Sciences. 2022; 18(1): 315-330.
8. YimingPan#,YuyouYang#, MengtianFan, ChengChen, RongJiang, LiLiang, MenglinXian, BiaoKuang, NanaGeng, Naibo Feng, Lin Deng, Wei Zheng, Fengmei Zhang, Xiaoli Li, Fengjin Guo*. Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis. Genes Dis., 2022 Jun 13;10(4):1582-1595.
9. Yuyou Yang#, Naibo Feng#, Li Liang, Rong Jiang, Yiming Pan, Nana Geng, Mengtian Fan, Xiaoli Li, Fengjin Guo*. Progranulin, a moderator of estrogen/estrogen receptor α binding, regulates bone homeostasis through PERK/p-eIF2 signaling pathway. J Mol Med.2022 Aug; 100(8):1191-1207.
10. W Zheng, W Xie, D Yin, R Luo, M Liu, Fengjin Guo*. ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling. Cell Commun Signal (IF=5.324, Q1). 2019 May 6;17(1):42.
（3）胚胎发育与表观遗传调控（向云龙教授团队）
主持国家自然科学基金面上项目2项，省部级科研项目1项，校级科研项目2项，累计科研经费500余万元。在学术刊物Nature Genetics、Cell Research等发表学术文章20多篇，论文引用2200余次，H-Index为15。
代表性论文（#第一作者，*通讯作者）
1.Wang XX#, Xiang YL#, Yu Y#, Wang R, Zhang Y, Xu QH, Sun H, Zhao ZA, Jiang XX, Wang XQ, Lu XK, Qin DD, Quan YJ, Zhang JQ, Shyh-Chang Ng, Wang HM, Jing NH, Xie W*, Li L*. Formative pluripotent stem cells show features of epiblast cells poised for gastrulation. Cell Research. 2021; 31:526–541. (# Equal contribution, * Corresponding author)
2. Xiang YL#, Zhang Y#, Xu QH, Zhou C, Liu BF, Du ZH, Zhang K, Zhang BJ, Wang XX, Gayen S, Liu L, Wang Y, Li YY, Wang QJ, Kalantry S, Li L, Xie W*. Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency. Nature Genetics. 2020; 52:95-105.
3. Xu QH#, Xiang YL#, Wang QJ#, Wang LY#, Amour J.B., Bogutz A.B., Zhang Y, Zhang BJ, Yu G, Xia WK, Du ZH, Huang CY, Ma J, Zheng H, Li YY, Liu C, Walker C. L., Jonasch E, Lefebvre L, Wu M, Lorincz M, Li W*, Li L*, Xie W*. SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development. Nature Genetics. 2019; 51:844-856.
4. Zhang Y#, Xiang YL#, Yin QZ#, Du ZH#, Peng X, Wang QJ, Fidalgo M, Xia WK, Li YY, Zhao ZA, Zhang WH, Ma J, Xu F, Wang JL, Li L, Xie W*. Dynamic epigenomic landscapes during early lineage specification in mouse embryos. Nature Genetics. 2018; 51:96-105.
（4）肾脏损伤的分子机制研究（张政教授团队）
主持国家自然科学基金项目5项，省部级科研项目3项，累计科研经费200多万元。在学术刊物发表学术文章70多篇，2篇高被引文章列入重庆医科大学临床医学ESI全球前1‰文章。任国家级规划教材副主编2部。
代表性论文（#第一作者，*通讯作者）
1. Yi H#, Peng R#, Zhang LY, Sun Y, Peng HM, Liu HD, Yu LJ, Li AL, Zhang YJ, Jiang WH, Zhang Z*. LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy. Cell Death Dis. 2017, 8(2):e2583.
2. Zhang PY#, Sun Y#, Peng R, Chen WY, Fu X, Zhang LY, Peng HM, Zhang Z*. Long non-coding RNA Rpph1 promotes the inflammation and mesangial cell proliferation via interacting with Gal-3 in diabetic nephropathy. Cell Death Dis. 2019,10(7):526-532.
3. Chen WY#, Peng R#, Sun Y, Liu HD, Zhang LY, Peng HM, Zhang Z*. The topological key lncRNA H2k2 from ceRNA network promotes mesangial cell proliferation via miR-449a/b/Trim11/Mek signaling pathway in diabetic nephropathy. FASEB J. 2019,33(10):11492-11506.
4. Lin ZY#, Lv D#, Liao XH#, Peng R, Liu HD, Wu TH, Wu KQ, Sun Y*, Zhang Z*. CircUBXN7 promotes macrophage infiltration and renal fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability in diabetic kidney disease. Front Immunol. 2023,14:1226962.
5. Lv D#, Lin Z#, Liao X#, Peng R, Liu H, Wu T, Wu K, Sun Y*, Zhang Z*. Sfrp2 promotes renal dysfunction of diabetic kidney disease via modulating Fzd5-induced cytosolic calcium ion concentration and CaMKII/Mek/Erk pathway in mesangial cells. Biochim Biophys Acta Mol Basis Dis. 2024,1870(2): 166933.
6. Guo TT#, Zhang Z#, Sun Y, Zhu RY, Wang FX, Ma LJ, Jiang L, Liu HD*. Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease. Nutrients. 2023,15(4),930.
7. Yang H#, Wang J#, Zhang Z#, Peng R, Lv D, Liu H, Sun Y*. Sp1-Induced lncRNA Rmrp Promotes Mesangial Cell Proliferation and Fibrosis in Diabetic Nephropathy by Modulating the miR-1a-3p/JunD Pathway. Front Endocrinol (Lausanne). 2021,12:690784.
（5）肺部炎症疾病、恶性肿瘤肺转移（任春光教授团队）
主持国家自然科学基金项目1项，省部级科研项目3项，累计科研经费近300万元。在学术刊物Developmental Cell、Cell Reports、Journal of Immunology等发表学术文章20多篇。
代表性论文（#第一作者，*通讯作者）
1. Zhou M#, Meng L#, He QK, Ren CG*, Li CY*. Valsartan attenuates LPS-induced ALI by modulating NF-κB and MAPK pathways. Frontiers in Pharmacology. 2024 Jan 15. 15:1321095.
2. Fan SJ#, Jiang JL#, Zhang H, Wang CH, Kong S, Zhao TT, Meng L, Liu Y, Qin JJ, Rong XQ, He ZT, He QK, He K, Chen KT, Lei L, Hai XY, Nie H*, Ren CG*. Identification of HDAC inhibitors as neutrophil recruitment modulators in zebrafish using a chemical library screen. Disease Models & Mechanisms. 2023 Oct 1;16(10):dmm050056.
3. Zhang H, Meng L, Liu Y, Jiang JL, He ZT, Qin JJ, Wang CH, Yang MT, He K, Yang J, Chen KT, He QK, Tang WW, Fan SJ*, Ren CG*. Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway. Journal of Immunology. 2023 Aug 1;211(3):462-473.
4. Ren CG#, Yuan QY, Jian XY, Randazzo PA, Tang WW, Wu DQ. Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization. Journal of Immunology. 2020 Feb 15;204(4):1012-1021.
5. Ren CG#, Yuan QY#, Braun M, Zhang X, Petri B, Zhang JS, Kim D, Guez-Haddad J, Xue WZ, Pan WJ, Fan R, Kubes P, Sun ZX, Opatowsky Y, Polleux F, Karatekin E, Tang WW, Wu DQ. Leukocyte cytoskeleton polarization is initiated by plasma membrane curvature from cell attachment. Developmental Cell. 2019 April 22；49, 206–219.
6. Chan EC#, Ren CG#, Xie Z, Jude JA, Barker T, Koziol-White CA, Ma M, Panettieri RA Jr, Wu D, Rosenberg HF, Druey KM. Regulator of G protein signaling 5 restricts neutrophil chemotaxis and trafficking. Journal of Biological Chemistry. 2018 Aug 17;293(33):12690-12702.
7. Yuan QY#, Ren CG#, Xu WW, Petri B, Zhang JS, Zhang Y, Kube P, Wu DQ, Tang WW. PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury. Cell Reports. 2017 June 20; 19(12):2586–2597.
8. Ren CG*, Wang L, Jia XE, Liu YJ, Dong ZW, Jin Y, Chen Y, Deng M, Zhou Y, Zhou Y, Ren RB*, Pan WJ*, Liu TX. Activated N-Ras signaling regulates arterial-venous specification in Zebrafish. Journal of Hematology & Oncology. 2013 May 12; 6:34.
9. Wang R#, Wang Y#, Liu N#, Ren CG#，Jiang C, Zhang K, Yu S, Chen YF, Tang H, Deng Q, Fu C, Wang YC, Li R, Liu MY, Weijun Pan, Ping Wang. FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Research. 2013. Jun;23(6):803-19.
5.荣誉与奖励
（1）荣誉：
文波教授：上海市曙光学者，上海市浦江人才，巴渝学者讲座讲授，重庆市首席专家工作室领衔专家，国家重大科学研究计划（973）首席科学家，教育部长江学者特聘教授，国家重大科学研究计划（973）首席科学家。
郭风劲教授：教育部“新世纪优秀人才”；重庆市“高等学校优秀人才”；重庆市“五四青年红旗手”。
向云龙教授：重庆市“巴渝学者”计划青年学者。
张政教授：重庆市学术技术带头人后备人选。
（2）奖励：
文波教授：云南省自然科学一等奖，全国优秀博士论文，上海市卫生系统优秀青年。
郭风劲教授：重庆市自然科学三等奖。
